Serotonin (5-HT) is a monoamine neurotransmitter that regulates a variety of behaviors and physiological processes, including circadian rhythms, sleep, appetite, aggressive behaviors, locomotion, perception, memory and learning, temperature regulation, mood, behavior, cardiovascular function, muscle contraction, and endocrine regulation.

The low level of serotonin may be associated with several disorders, such as increase in aggressive and angry behavior, clinical depression, Parkinson’s disease, obsessive-compulsive disorder, eating disorder, migraine, irritable bowel syndrome, abnormal defecation, and bipolar disease. These effects are mediated via different serotonin (5-HT) receptors. In mammals, there are in total 14 different kinds of receptors which can be strictly categorized into 7 large groups. 5-HT7 receptors belong to the G-protein-coupled receptor (GPCR) superfamily. It can stimulate cAMP formation.

The 5-HT7 serotonin receptor agonist (LP44) is a compound that activates serotonin receptors in a manner similar to serotonin. The 5-HT7 serotonin receptor agonist has high affinity for 5-HT1A and 5-HT2A receptors. 5-HT1A   agonists, similar to anxiolytics, are recently used as antidepressants. 5-HT2A agonists work for “psychedelic” effects, but not all 5-HT2A agonists are psychoactive.

According to electrophysiological, neurochemical, and neuropharmacological studies, it is generally accepted that serotonin (5-HT) functions to promote waking and to inhibit rapid-eye-movement sleep (REMS). In the experiment, the 5-HT7 receptors have been found to be discretely localized in both terminal regions and cell body regions in rat tissues, participating in the regulation of slow-wave sleep, rapid-eye-movement sleep (REMS), and waking. If the 5-HT7 serotonin receptor agonist (LP44) (1.25 to 5.0 mM) is injected into the DRN (the dorsal raphe nucleus) of the rat during the light phase, it would induce a reduction of REMS and of the number of REMS periods (Héctor, J., Marcello, L., & Jaime, M. M., 2008).

The 5-HT7 serotonin receptors are present in a variety of human tissues, particularly in the brain, the gastrointestinal tract, and in various blood vessels. Serotonin is a neurotransmitter and plays an important role in a variety of cognitive and behavioral functions, such as the vasculature system, the smooth muscle relaxation, and the gastrointestinal tract. Both the thalamus and the hypothalamus contain high densities of 5-HT7 receptors, and so do the hippocampus and the cortex. Serotonin (5-HT) is involved in thermoregulation, circadian rhythms, learning, memory, sleep and, mood adjustment. Therefore it can be helpful for the treatment of depression.

The 5-HT7 receptors are present in various regions of the central nervous system, indicating a potential for therapeutic intervention in a variety of neuropsychiatric diseases. Particularly in brain regions (the suprachiasmatic nuclei), 5-HT7 receptors can participate in the regulation of circadian rhythms and affect sleep, rest and activity.

The recent findings in medicine indicate that the 5-HT7 serotonin receptor agonist can be used for the treatment of pain and the symptoms of pain, especially certain subtypes of pain like neuropathic pain and inflammatory pain and symptoms involving allodynia and hyperalgesia (Romero-Alonso, L., Buschmann, H. H., Torrens-Jover, A., & Hernandez, J. M. V., 2008). Therefore 5-HT7 serotonin receptor agonist is also regarded as an analgesic, especially in neuropathic pain.

In 1989, Mr. Yuan Lin discovered the Absolutely Constant Energy Source (ACES). He utilized ACES to activate the genome responsible for inheritance, development and performance of body functions in the human body to control specific amino acid sequences and protein peptide formation processes, directing cell division, replication and new organelle formation. ACES was also applied to affect changes in the irreversible process of spontaneous biochemical reactions of carbohydrates, lipids, proteins, amino acids, enzymes, nucleic acids, vitamins, hormones and trace elements. Mr. Yuan Lin thus had his body experience an unprecedented leap forward in human evolution, which had thoroughly changed the human biological form, structure, and habits inherited over billions of years, to become the first successfully-evolved New Human Line.

The purpose of this experiment is to prove that Mr. Yuan Lin, the first successfully-evolved New Human Line, can utilize the Absolutely Constant Energy Source and the new biological engineering techniques to activate the 5-HT7  serotonin receptor agonist and control its concentration without any change in its molecular weight, structural formula, and conformation, at 25 ℃, 1.0 atm, and pH 7.0, in a confined and isolated space, and with no contact with catalysts, biologically active substances, chemical substances, and physical action forces, and also by means of changes in the concentration of  the 5- HT7  serotonin receptor agonist to control the biochemical reactions induced by this agonist.

Table 1. Comparison of the absorbance between two treatments at 233 nm

From the above experimental results, we can see that there is significant difference（p=0.001）in the concentration between the control samples and the samples treated with ACES by Mr. Yuan Lin. It proved that Mr. Yuan Lin, the New Human Line, can utilize the Absolutely Constant Energy Source and the new biological engineering techniques to activate the 5-HT7  serotonin receptor agonist and change its concentration, and also, by means of changes in its concentration, to control the biochemical reactions induced by this agonist so as to precisely control and regulate the functioning of the human body to activate higher-level evolution.

References：